This provides a Particle comprising a viral Antigen and viral Structural Protein or a Derivative of pd-1 ligand PD - 1 and a composition or kit that includes their use in immune response, etc.Claim: The 4 Particle according to claim 1, wherein the particle is a Particle of chikungunya virus type that consists of one or several Envelope Protein E2, where is inserted the pd-1 Antigen derived from one or several Proteins The Casing and one or several capsids are and where the Envelope Protein E2.Where is inserted the pd-1 Antigen derivative is an Amino Acid Sequence represented by SEQ ID no. 33 - 35； the Envelope Protein is an Amino Acid Sequence represented by SEQ ID no. 37； and the capsid is an Amino Acid Sequence represented For SEQ ID no. 38.Claim 14: Use of the particle according to any one of claims 1 - 8The Nucleic Acid Molecule according to any one of claims 1 - 11 and / or vector according to claim 11 wherein is for the production of a Pharmaceutical Composition and a Kit for treating or Preventing cancer or an infectious disease； Production An Antibody against pd-1 or a ligand of pd-1 in a Mammal； Modulation of an immune response； immuneSTimulation and inhibition of an interaction between pd-1 and pd-1 ligand； or inhibiting activity of pd-1.La presente proporciona una partícula de tipo viral que comprende una proteína estructural viral y un antígeno derivado de PD-1 o un ligando de PD-1 y una composición o kit que la comprende, su uso en la respuesta inmune, etc.. Reivindicación 4: La partícula de acuerdo con cualquiera de las reivindicaciones 1 - 3, caracterizada porque la partícula es partícula de tipo virus Chikungunya que consiste en una o varias proteínas de envoltura E2, en donde se inserta el antígeno derivado de PD-1, una o varias proteínas de envoltura El y una o varias cápsides y en donde la proteína de envoltura E2, en donde se inserta el antígeno derivado de PD-1 consiste en una secuencia de aminoácidos representada por SEQ ID Nº 33 - 35； la prot
