ADAMS CHRISTOPHER MICHAEL,CHAMOIN SYLVIE,HU QI YING,ZHANG CHUN
申请号：
IN8846/DELNP/2011
公开号：
IN2011DN08846A
申请日:
2011.11.14
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention provides a compound a formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is CH2, O, S or-NR1 each R1 are independently C1-7alkyl or C3-8cycloalkyl each of R and R are independently hydrogen, halogen, cyano, C1-7alkyl, hydroxy-C1-7alkyl, -OR7, C3-8cycloalkyl, halo-C1-7alkyl or -CH2-NR8-SO2-R10 R3 and R4 are independently hydrogen, halogen or cyano R5 is hydrogen, C1-2alkyl, halogen, cyano, hydroxy, hydroxy-C1-7alkyl, hydroxy-C3-8 cycloalkylalkyl, C1-7alkoxy-C3-3alkyl, -OR7, C6-10aryl, heteroaryl, heterocyclyl, C3-8 cycloalkyl, halo- C1-7alkyl, -NR8R9, -CH2NR8-C(O)NR8R9, -CH2-NR6-SO2-R10, -C(O)- R10 -SO2R10, -C(O)-NR5R9 -SO2-NR8R9, -NR3C(O)-R10 -CH2CN, or -NR8-SO2-R10. Compounds of the invention may be useful in the treatment of a disorder or disease mediated by aldosterone synthase and/or 11-beta hydroxylase (CYP1 181).
