Flohr, Stefanie,Hommel, Ulrich,Lorthiois, Edwige Liliane Jeanne,Maibaum, Juergen Klaus,Ostermann, Nils,Randl, Stefan Andreas,Vulpetti, Anna,Quancard, Jean
申请号：
ES13762559
公开号：
ES2648962T3
申请日:
2013.06.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound according to formula (II): ** Formula ** or a salt thereof, where A is a group selected from: Z1 is C (R1) or N； Z2 is C (R2) or N； Z3 is C (R3) or N, where at least one of Z1, Z2 or Z3 is not N； R1 is selected from the group consisting of hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy, haloC-C6alkyl, haloC-C6alkoxy C1-C6alkoxycarbonyl, CO2H and C (O) NRARB； R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, NRCRD, cyano, CO2H, CONRARB SO2C1-C6alkyl, and SO2NH2, SO2NRARB, C1-C6alkoxycarbonyl, -C (NRA) NRCRD, C1-C6alkyl, haloC1 -C6alkyl, C2-C6alkenyl, C1-C6alkoxyl, haloC1-C6alkoxy, C2-C6alkenyloxy, where each alkyl, alkenyl, alkoxy and alkenyloxy is not substituted or substituted with up to 4 substituents independently selected from halogen, hydroxyl, cyano, tetrazol , C1-C4alkoxy, C1-C4haloalkoxy, CO2H, C1-C6alkoxycarbonyl, C (O) NRARB, NRCRD, optionally substituted phenyl, heterocycle with between 4 and 7 ring atoms and 1, 2, or 3 ring heteroatoms to be select from N, O or S, heteroaryl optionally substituted with 5 or 6 ring atoms and 1 or 2 or 3 ring heteroatoms that are selected from N, O or S, and where the optional phenyl and heteroaryl substituents are selected from halogen, hydroxyl, C1-C4alq uyl, C1-C4alkoxy and CO2H； R4 is selected from the group consisting of hydrogen, halogen, and C1-C6alkyl； R5 is C1-C4alkyl, hydroxyC1-C4alkyl, C1-C4alkoxyC1-C4alkyl, haloC1-C4alkyl, amino, methylamino R6 is hydrogen； R7 is hydrogen or fluorine； R8 is hydrogen, methyl or hydroxymethyl； R9 is hydrogen, halogen, hydroxyl or methoxy； or R6 and R7, taken together, form a cyclopropane ring, or R8 and R9, taken together, form a cyclopropane ring, R10 and R11 are independently selected from hydrogen, halogen, C1-C4alkyl, hydroxyC1-C4alkyl, C1-C4alkoxyC1-C4alkyl and haloC1-C4alkyl； or R10 and R11 taken together may form a 3- or 6-membered carbocycle or heterocycle containing 1 O or S heteroatom optionally substituted with 1 or 2
