HADIDA RUAH SARA,GROOTENHUIS PETER D J,ZHOU JINGLAN,BEAR BRIAN,MILLER MARK,MCCARTNEY JASON
申请号：
IN201638001937
公开号：
IN201638001937A
申请日:
2016.01.19
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A compound of formula VI: or a pharmaceutically acceptable salt thereof, wherein: each R1 is: m is 0-4 RP is optionally substituted C1-C6 aliphatic, wherein up to two carbon units therein are optionally and independently replaced by -CO-, -CONRN-, -CO2-, -OCO- , -NRNCO2-, -O-, -OCONRN-, -NRNCO-, -S-, -SO-, -SO2-, -NRN- RM is independently -ZMR11, wherein each ZM is independently a bond or an optionally substituted branched or straight C1- C6 aliphatic chain wherein up to two carbon units of ZM are optionally and independently replaced by -CO-, -CONRN-, -CO2-, -OCO-, -CHRN-, -NRNCO2-, -O-, -OCONRN-, -NRNCO-, - S-, -SO-, -SO2-, -NRN- R� is independently RN, halo, -OH, -NH2, -CN, -CF3, or -OCF3 RN is independently hydrogen, an optionally substituted C1-C8 aliphatic group, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl R1 is an optionally substituted C1-C6 aliphatic, an optionally substituted C1-6 alkoxy, an optionally substituted C3-C10 cycloaliphatic, -CN, halo, or hydroxy R2 is hydrogen or an optionally substituted C1-C6 aliphatic R3 and R3 together with the carbon atom to which they are attached form an optionally substituted C3-C7 cycloaliphatic or an optionally substituted heterocycloaliphaticR4 is an optionally substituted aryl and n is 0-3.
