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THALASSEMIA TREATMENT METHODS
专利权人:
ТАРГЕДЖЕН; ИНК. (US)
发明人:
ХУД Джон Д. (US)
申请号:
RU2011108563/15
公开号:
RU2011108563A
申请日:
2009.08.03
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of treating, alleviating or slowing the manifestation of at least one symptom of thalassemia in a patient in need thereof, which comprises administering a therapeutically effective amount of a compound represented by formula I:! ! where A is selected from the group consisting of alkylene or NR1; ! Q is monocyclic or bicyclic aryl, or monocyclic or bicyclic heteroaryl bonded to A via ring carbon,! while Q can be additionally substituted by 1, 2 or 3 substituents, each of which is independently selected from the group consisting of: halogen, hydroxyl, cyano, amino, nitro, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1- C6 alkoxy, NR1R1 ', amido, carboxyl, alkanoyl, alkoxycarbonyl, ureido, N-alkylsulfamoyl, N-alkylcarbamoyl, carboxamide, sulfamoyl, carbamoyl, heteroaryl, heterocycle, -NR1-C (O) -NR2N-alkyl ; SO2NH heterocycle, SO2H, SO2- (C1-C6) alkyl, SO2-heterocycle or C (O) heterocycle, where the heterocycle, phenyl or cycloalkyl in each case, if any, may be further substituted with C1-C6 alkyl; ! R1 and R1 ′ in each case may independently be selected from H or C1-C6 alkyl; ! R5 represents H, halogen, cyano or C1-C6 alkyl; ! B represents N or CR2; ! R2 is selected from the group consisting of H, halogen, C1-C6 alkyl, C1-C6 alkoxy or alkoxycarbonyl; ! Y is selected from the group consisting of: bond, -O-alkylene; -SO2-, SO2-NR1-alkylene-, -O-, alkylene and -C (O) -; ! R3 is selected from the group consisting of H, halogen, hydroxyl and R4, where R4 is a monocyclic heterocycle or heteroaryl bonded to Y via a ring carbon or heteroatom, and where R1 can be further substituted with 1, 2 or 3 substituents, each of which�1. Способ лечения, облегчения или замедления проявления по крайней мере одного симптома талассемии у нуждающегося в этом пациента, который включает введение терапевтически эффективного количества соединения, представленного формулой I: ! ! где А выбирается из группы, включающей алкилен или NR1; ! Q является моноциклическим или бициклически
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