ABBOT, SARAH C.,BOICE, GENEVIEVE N.,BUETTELMANN, BERND,GOLDSTEIN, DAVID MICHAEL,GONG, LEYI,HOGG, JOAN HEATHER,IYER, PRAVIN,MCCALEB, KRISTEN LYNN,TAN, YUN-CHOU
申请号：
ES08759523
公开号：
ES2382137T3
申请日:
2008.05.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of the formula I ** Formula ** wherein X is CR11 or N； Y is -C (O) R3, 5-membered heteroaryl or member heterocyclyl； Z is phenyl, cycloalkyl, heterocyclyl or heteroaryl, and is substituted with R1 and R2； R1 and R2 are each, independently, H, halogen, CN, C1-C6 alkyl, or -Y1-Y2-Y3-R8, or R1 and R2 together form -O-CH2) nO- where n is 1 or 2 ； Y1 is -O-, -C (O) -, -C (O) O-, -C (O) NR9-, -NR9C (O) -, -S-, -SO2- or a bond； Y2 is cycloalkylene, heterocycloalkylene, C1-C6 alkylene or a bond； Y3 is -O-, -C (O) -, -C (O) O-, -C (O) NR9-, -NR9C (O) -, -SO2- or a bond； R8 is H, C1-C6 alkyl, C1-C6 alkoxy, cycloalkyl, heterocycloalkyl or -NR9R10, wherein when R8 is other than H, then it is optionally substituted by C1-C6 alkyl, halogen, CF3, or -OH； R9 and R10 independently of one another are H or C1-C6 alkyl； R3 is OH, C1-C6 alkyl, C1-C6 alkoxy, (C1-C6 alkoxy) -C1-C6 alkoxy, or -NR9R10； R4 is C1-C6 alkyl, phenyl, heterocyclyl, cycloalkyl, heterocycloalkyl, or heteroaryl, and is optionally substituted by C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halogen, nitro, amino, cyano, or halo-C1-C6 alkyl ； R5 and R6 are each, independently of each other, H, halogen, cyano, C1-C6 alkyl, -CF3, C1-C6 alkoxy, -OCHF2, -NO2 or -NR9R10； R7 is H, F, Cl, methyl or OH； R11 is H, C1-C6 alkyl, lower cycloalkyl or phenyl； or a pharmaceutically acceptable salt thereof.Un compuesto de la fórmula I**Fórmula** en donde X es CR11 o N； Y es -C(O)R3, heteroarilo de 5-miembros o heterociclilo de miembros； Z es fenilo, cicloalquilo, heterociclilo o heteroarilo, y está sustituido con R1 y R2； R1 y R2 son cada uno, independientemente, H, halógeno, CN, alquilo C1-C6, o -Y1-Y2-Y3-R8, o R1 y R2 juntos forman -O-CH2)nO- en donde n es 1 o 2； Y1 es -O-, -C(O)-, -C(O)O-, -C(O)NR9-, -NR9C(O)-, -S-, -SO2- o un enlace； Y2 es cicloalquileno, heterocicloalquileno, alquileno C1-C6 o un enlace； Y3 es -O-, -C(O)-, -C(O)O-, -C(O)NR9-, -NR9C(O)-, -SO2- o un enlace； R8 es H, alquilo C1-C6, alcoxi C1-C6, cicloalquilo, hete
