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ПРОИЗВОДНЫЕ АЗЕТИДИНОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ
专利权人:
发明人:
Jean-Francois,Жан-Франсуа
申请号:
EA201070758
公开号:
EA019315B1
申请日:
2008.12.16
申请国别(地区):
EA
年份:
2014
代理人:
摘要:
The present invention provides the compounds conforming to the formula (I)in which R represents a (C1-C6) alkyl or halo (C1-C6) alkyl group R represents a group NR4R5 or OR8 A and B, when present, represent independently of one another, represent -CH2- R1 represents a hydrogen atom or a (C1-C6) alkyl group R2 and R3 represent, independently of one another, a hydrogen atom or a (C1-C6) alkyl wherein the (C1-C6) alkyl group being optionally substituted by one several substituents selected from hydroxy-, (C1-C6) alkoxy, halogen (C1-C6) alkyl-S(O)p, NR4R5 OR CONR4R5 R4 and R5 represent, independently of one another, a hydrogen atom or a (C1-C6) alkyl group, or form, with the nitrogen atom which carries them, a heterocycle selected from azetidine, pyrrolidine, piperidine, azepan, piperazine, homopiperazine, morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide type, this heterocycle being optionally substituted by a (C1-C6) alkyl R6 and R7 each represent a phenyl group, which is optionally substituted by one or several substituents selected from halogen, (C1-C6) alkyl, halogen (C1-C6) alkyl, (C1-C6) alkoxy, halogen (C1-C6) alkoxy or cyano Y represents a hydrogen atom, a halogen or a (C1-C6) alkyl, halogen (C1-C6) alkyl, (C1-C6) alkoxy, halogen (C1-C6) alkoxy group, (C1-C6) alkyl-S(O)p or cyano group R8 is a hydrogen atom, a (C1-C6) alkyl, a halogen (C1-C6) alkyl group, an allyl group or a phenyl (C1-C6) alkyl group, wherein the phenyl group being optionally substituted by 1 or 2 O-methyl groups p represents an integer selected from 0, 1 and 2 in the form of the base or an addition salt with an acid or with a base. Preparation process and application in therapy.Изобретение относится к соединениям, соответствующим формуле (I)в которой R обозначает (C1-C6) алкил или галоген (C1-С6) алкил R обозначает NR4R5 или OR8 А и В в случае их наличия независимо друг от друга обозначают -СН2- R1 обозначает атом водорода или (C1-C6) алкил R2 и R3 независимо друг
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