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ФЕНИЛИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ
专利权人:
OTSUKA FARMASJUTIKAL FEHKTORI; INK.
发明人:
SIBUTANI TADAO,СИБУТАНИ Тадао,IVATA KOUSI,ИВАТА Коуси,KIDO SATOSI,КИДО Сатоси
申请号:
RU2011136719/04
公开号:
RU0002497811C2
申请日:
2010.02.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to organic chemistry, namely to new phenylimidazole derivatives of general formula , wherein R1 represents a hydrogen atom, a phenyl lower-alkyl group or a pyridyl lower-alkyl group with a benzene ring and a pyridine ring are optionally substituted by 1 or 2 substitutes specified in a group consisting of halogen atoms, cyano group and halogen-substituted lower-alkyl groups one or R2 and R3 represents a hydrogen atom, and another one represents a lower alkoxy group R4 represents a lower-alkyl group, a difurylglyoxal group, a thienyl group or a phenyl group optionally substituted by 1 or 2 substitutes specified in a group consisting of lower-alkyl groups, lower-alkoxy groups, halogen atoms, a carboxyl group, lower alkoxycarbonyl groups, and halogen-substituted lower-alkyl groups R5 and R6 are identical or different, and represent a hydrogen atom or a lower alkyl group R7 and R8 are identical or different, and represent a hydrogen atom or a lower alkoxy group provided R1 represents an unsubstituted phenyl lower-alkyl group, R2 represents a lower alkoxy group, R3 represents a hydrogen atom, R4 represents an unsubstituted phenyl group or a phenyl group containing 1 or 2 halogen-substituted lower-alkyl groups, and R5 represents a hydrogen atom, then R6 is other than a hydrogen atom. Also, the invention refers to an LPL activator, an agent for preventing or treating hyperlipidaemia, an agent for treating arteriosclerosis, and an agent for treating obesity on the basis of the compound of formula (1).EFFECT: there are prepared new phenylimidazole derivatives effective for LPL activation.23 cl, 10 tbl, 7 exНастоящее изобретение относится к области органической химии, а именно к новым производным фенилимидазола общей формулы (1), где R1 представляет собой атом водорода, фенил-низшую алкильную группу или пиридил-низшую алкильную группу, причем бензольное кольцо и пиридиновое кольцо необязательно замещены 1 или 2
来源网站:
中国工程科技知识中心
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