A coating material for enhancing durability is provided to show excellent cell activation and blood circulation promoting activities when applied to muscular skin of hands and feet, thereby exerting excellent durability increasing effect on muscle. A coating material for enhancing durability comprises: nucleoprotein and/or a decomposition product including 20-50 wt.% of a fraction having a molecular weight of 1,000-3,000 obtained by low molecularizing DNA through enzyme decomposition or hydrolysis, or deoxyoligonucleotide, deoxymononucleotide or oligopeptide isolated from the decomposition product； or a decomposition product including 20-50 wt.% of a fraction having a molecular weight of 1,000-3,000 obtained by low molecularizing RNA through enzyme decomposition or hydrolysis, or oligonucleotide or mononucleotide isolated from the decomposition product； or a mixture of at least two selected from the group consisting of the nucleoprotein and/or the DNA decomposition product, the RNA decomposition product, the deoxyoligonucleotide, the deoxymononucleotide, the oligopeptide, the oligonucleotide and the mononucleotide, wherein the nucleoprotein and DNA are obtained from milt of fish selected from the group consisting of salmon, trout, herring and codfish, and the RNA is obtained from a yeast selected from the group consisting of beer yeast, torula yeast, milk yeast and bread yeast.본 발명은 세포 활성화 효과 및 혈액순환 촉진 효과를 갖는 내구력 증강 도포제를 제공한다.본 발명은 뉴클레오프로테인 및/또는 DNA 또는 RNA의 효소분해 생성물 또는 가수분해 생성물, 상기 분해생성물로부터 분리된 디옥시올리고뉴클레오티드, 디옥시모노뉴클레오티드, 올리고펩티드, 올리고뉴클레오티드, 모노뉴클레오티드, 또는 상기 분해 생성물 또는 상기 화합물로부터 선택된 적어도 2종의 혼합물을 유효성분으로 함유하는 내구력 증강 도포제에 관한 것이다. 본 발명에 따른 내구력 증강 도포제를 적용시킬 수 있는 대상은 사람뿐만 아니라 말, 개 등과 같이 레이스를 하는 포유동물에 대해서도, 내구력 증강을 위해 이용할 수 있다.
