A compound of formula (I) and the tautomeric forms thereof of formulas (II) and (III) or a salt, hydrate, solvate, or N-oxide thereof: ** Formula ** wherein X is -N- , -CH2-N-, -CH2-CH-, or -CH-； R1 is a radical of formula (IA) ~ ** Formula ** wherein Z is -CH2-, -NH-, -O-, -S (O) - S, SO2 or a divalent monocyclic carbocyclic or heterocyclic radical having 3-7 atoms in the ring； Alk is an optionally substituted divalent C1-C6 alkylene radical； A is a hydrogen or an optionally substituted monocyclic carbocyclic or heterocyclic ring having 5-7 ring atoms； r, s and t are independently 0 or 1, as long as A is hydrogen then at least one of r and s is 1； R2 is halogen, -CN, -CF3, -OCH3, or cyclopropyl； and R3 is a radical of formula (IB) ** Formula ** wherein Q is hydrogen or an optionally substituted phenyl or a monocyclic heterocyclic ring with 5 or 6 ring atoms； Z1 is -S-, -S (O) -, -S (O) 2-, -O-, -SO2NH-, -NHSO2-, NHC (>； = O) NH, -NH (C>； = S) NH -, or -N (R4) - wherein R4 is hydrogen, C1-C3 alkyl, cycloalkyl, or benzyl； and Alk1 and Alk2 are, independently, optionally substituted divalent C1-C3 alkylene radicals； and m, n and p are independently 0 or 1； and where the term "optionally substituted" means substituted with up to four compatible substituents, each of which may independently be, for example, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C1-C6) alkoxy including methylenedioxy and ethylenedioxy, hydroxy, hydroxy (C1-C6) alkyl, mercapto, mercapto (C1-C6) alkyl, alkylthio (C1-C6), phenyl, monocyclic heterocyclic, benzyl, phenoxy, halo (including fluorine, bromine and chlorine), trifluoromethyl , trifluoromethoxy, nitro, nitrile (- CN), oxo, -COOH, -COORA, -CORA, -SO2RA, -CONH2, -SO2NH2, -CONHRA, - SO2NHRA, -CONRARB, -SO2NRARB, -NH2-, - NHRA, -NRARB, -OCONH2, -OCONHRA -OCONRARB, -NHCORA, -NHCOORA, -NRBCOORA, -NHSO2ORA, -NRBSO2OH, - NRBSO2ORA, -NHCONH2, -NRACONH2, - NHCONHRB, -NRACONHRBON -RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RBON-RB
