TSUI, PING,BORROK, MARTIN,DALL'ACQUA, WILLIAM,DALLACQUA, WILLIAM
申请号：
CA2871934
公开号：
CA2871934A1
申请日:
2013.04.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
