Tsui, Ping,Borrok, Martin,Dall'Acqua, William,DallAcqua, William
申请号：
AU2018201534
公开号：
AU2018201534A1
申请日:
2018.03.02
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018201534A120180322.pdf#####ABSTRACT Provided are polypeptides comprising a variant IgG Fe domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
