Molecules with reduced effector function and extended half-lives, compositions, and uses thereof

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专利权人:

MedImmune; LLC

发明人:

Ping Tsui,Martin Borrok, II,William Dall'Acqua,William DallAcqua

申请号：

US14397958

公开号：

US10011660B2

申请日:

2013.04.17

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/