Molecules with reduced effector function and long half-lives, compositions and uses thereof

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专利权人:

MedImmune; LLC

发明人:

TSUI, Ping,BORROK, Martin,DALL'ACQUA, William

申请号：

ES13784604

公开号：

ES2746103T3

申请日:

2013.04.17

申请国别(地区):

ES

年份:

2020

代理人:

摘要：

Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/