LEONI, LORENZO,MAJ, ROBERTO,PATTARINO, FRANCO,VECCHIO, CARLO
申请号：
ES10703023
公开号：
ES2450420T3
申请日:
2010.02.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Pharmaceutical composition comprises an imidazoquinolin (amine) and lactic acid for use in the treatment of bladder diseases, characterized in that the imidazoquinolin (amine) in the pharmaceutical composition is selected from a compound defined by one of the following groups (a), ( b) and (c): a) 1 H -imidazo [4,5-c] quinolin-4-amine； b) an imidazoquinolin (amine) compound selected from the following formula (I): ** Formula ** where R1, R2, and R3 are independently selected, in each case, from hydrogen； cycloalkylalkyl of three, four or five carbon atoms； linear or branched chain alkyl of one to ten carbon atoms and substituted straight or branched chain alkyl of one to ten carbon atoms, the substituent being selected from the group consisting of cycloalkyl of three to six carbon atoms and cycloalkyl of three to six carbon atoms substituted with a linear or branched alkyl of one to four carbon atoms； fluoro- or chloroalkyl of one to ten carbon atoms and with one or more fluorine or chlorine atoms； linear or branched alkenyl of two to ten carbon atoms and linear or branched alkenyl of two to ten substituted carbon atoms, wherein the substituent is selected from the group consisting of cycloalkyl of three to six carbon atoms and cycloalkyl of three to six atoms of carbon substituted with linear or branched alkyl of one to four carbon atoms； hydroxyalkyl of one to six carbon atoms； alkoxyalkyl, where the alkoxy part has one to four carbon atoms and the alkyl part has one to six carbon atoms； acyloxyalkyl, where the acyloxy part is an alkanoyloxy of two to four carbon atoms or benzoyloxy, and the alkyl part has one to six carbon atoms, with the proviso that any alkyl, substituted alkyl, alkenyl, substituted alkenyl, hydroxyalkyl group , alkoxyalkyl or acyloxyalkyl does not have a fully substituted carbon atom the carbon bonded directly to the nitrogen atom； benzyl； (phenyl) ethyl； and phenyl； wherein the benzyl, (phenyl) ethyl or the phenyl substituent is optionally su
