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Pyrrole and indole Derivatives, their process of Preparation and Pharmaceutical compositions containing them
专利权人:
LES LABORATOIRES SERVIER;VERNALIS (R&D) LTD.
发明人:
SIMON BEDFORD,DANIEL MADDOX,STUART RAY,CHRISTOPHER JOHN GRAHAM,CLAIRE WALMSLEY,I CHEN,JAMES BROOKE JEN - MURRAY,JAMES EDWARD PAUL DAVIDSON,OLIVIER GENESTE,GUILLAUME DE NANTEUIL,ARNAUD LE TIRAN,JRME ST
申请号:
ARP140102679
公开号:
AR099914A1
申请日:
2014.07.21
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
Requirement 1: it consists of the following formula (1): W represents group c-a3 or nitrogen atom; A1,A² and A³ independently represent each other a hydrogen or halogen atom, a linear or branched C₁₋₆ polyhaloalkyl, a linear or branched C₁₋₆ alkyl group or a cycloalkyl, or A¹ and A² form with the atoms of carbon to which a cycloalkyl or a benzo cycle are attached, these two groups being optionally substituted with a halogen atom, a linear or branched C₁₋₆ alkyl group, linear or branched C₁₋₆ polyhaloalkyl, hydroxy, C₁₋₆ linear alkoxy or branched or -COOH,it being understood that W necessarily represents a C-A³ group when A¹ and A² independently represent each other a hydrogen or halogen atom, a linear or branched C₁₋₆ polyhaloalkyl, a linear or branched C₁₋₆ alkyl group or a cycloalkyl; T represents a hydrogen atom, a linear or branched C₁₋₆ alkyl group optionally substituted with one to three halogen atoms, a C₁₋₄-NR¹R² alkyl group,O c83318324-r8310a, rental group c8332121;R¹ and R² independently represent each other a hydrogen atom or a linear or branched C₁₋₆ alkyl group, or R¹ and R² form with the nitrogen atom to which a heterocycloalkyl is attached; R³ represents a linear or branched C₁₋₆ alkyl, C₂₋₆ linear or branched alkenyl, C₂₋₆ linear or branched alkynyl, cycloalkyl, C o linear or branched Calalkyl, heterocycloalkyl, aryl or heteroaryl group, it being understood that one or several carbon atoms of the above groups, or carbon atoms of their possible substituents, may (n) be deuterated (s);R83088 is an arilo, heteromorphic, cyclopentyl, c8321s 83316263 linear or branched compound, on the understanding that one or more carbon atoms in the above group, or the carbon atoms it may replace, may have failed;R⁵ represents a hydrogen or halogen atom, a linear or branched C₁₋₆ alkyl group, or a linear or branched C₁₋₆ alkoxy group; R⁶ represents a hydrogen atom or a linear or branched C₁₋₆ alkyl group; Rᵃ,R74955,R758080 and r74966 represent r8311a and r8311a respect
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