JANG, MYUNG HYUN,KIM, DAE JIN,HWANG, SANG YOUN,KIM, HYUN UK,JUNG, SUNG YOUB,KWON, SE CHANG
申请号：
CA2899418
公开号：
CA2899418A1
申请日:
2014.02.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to: an insulin conjugate, wherein a non-peptidic polymer and an immunoglobulin Fc region are site-selectively connected, by a covalent bond, to an amino acid residue of a region excluding the N terminal of insulin ß chain, and thus the binding force to an insulin receptor is improved, thereby increasing activity； an extended release preparation containing the same； and a method for preparing the same. The insulin conjugate of the present invention can provide an insulin preparation with remarkably improved in vivo activity of a peptide.
