Jang, Myung Hyun,Kwon, Se Chang,Kim, Dae Jin,Jung, Sung Youb,Hwang, Sang Youn,Kim, Hyun Uk
申请号：
NZ71056414
公开号：
NZ710564A
申请日:
2014.02.26
申请国别(地区):
NZ
年份:
2020
代理人:
摘要：
The present invention relates to: an insulin conjugate, wherein a non-peptidic polymer and an immunoglobulin Fc region are site-selectively connected, by a covalent bond, to an amino acid residue of a region excluding the N terminal of insulin β chain, and thus the binding force to an insulin receptor is improved, thereby increasing activity； an extended release preparation containing the same； and a method for preparing the same. The insulin conjugate of the present invention can provide an insulin preparation with remarkably improved in vivo activity of a peptide.
