BOCK, Mark Gary,GAUL, Christoph,GUMMADI, Venkateshwar Rao,SENGUPTA, Saumitra
申请号：
ES12718554
公开号：
ES2656218T3
申请日:
2012.04.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I): ** (See formula) ** where: R1 is: (i) phenyl optionally substituted with 1 to 3 substituents selected from halogen, -CN, -OH, alkyl (from 1 to 6 carbon atoms), halogen-substituted alkyl (1 to 6 carbon atoms), alkoxy (1 to 6 carbon atoms), -NH2, -NHalkyl (1 to 4 carbon atoms), -N ( alkyl (from 1 to 4 carbon atoms)) 2, -NHC (O) -alkyl (from 1 to 4 carbon atoms), -C (O) NH2, -C (O) -NHalkyl (from 1 to 4 atoms carbon), -C (O) -N (alkyl (1 to 4 carbon atoms)) 2, cycloalkyl (3 to 5 carbon atoms), or a 5- to 6-membered heterocycle, (ii) fused phenyl with an additional phenyl, a 5- to 6-membered heteroaryl, a partially or fully saturated 5 to 6 membered cycloalkyl, or a partially or fully saturated 5 to 6 membered heterocycle, wherein said fused phenyl is optionally substituted with 1 to 4 substituents , each independently selected to from halogen, -CN, alkyl (from 1 to 6 carbon atoms), alkoxy (from 1 to 6 carbon atoms), alkyl (from 1 to 4 carbon atoms) substituted by hydroxyl, alkyl (from 1 to 4 atoms carbon) substituted by halogen, cycloalkyl (from 3 to 5 carbon atoms), oxo, -NH2, -NHalkyl (from 1 to 4 carbon atoms), -N (alkyl (from 1 to 4 carbon atoms)) 2 , -NHC (O) -alkyl (1 to 4 carbon atoms), or>； = N-OH, (iii) 5- to 6-membered heteroaryl optionally substituted with 1 to 3 substituents, each independently selected from halogen , -CN, -OH, alkyl (from 1 to 6 carbon atoms), alkyl (from 1 to 6 carbon atoms) substituted by halogen, alkoxy (from 1 to 6 carbon atoms), -NH2, - NH-alkyl (from 1 to 4 carbon atoms), -N (alkyl (from 1 to 4 carbon atoms)) 2, -NHC (O) -alkyl (from 1 to 4 carbon atoms), -C (O) NH2, -C (O) -NHalkyl (from 1 to 4 carbon atoms), -C (O) -N (alkyl (from 1 to 4 carbon atoms)) 2, cycloalkyl (from 3 to 5 carbon atoms), or a 5- to 6-membered heterocycle, or (iv) 5- to 6-membered heteroaryl fused to another 5- to 6-membered heteroaryl, phenyl, 5- to 6-membered cycloalkyl, partially or fully saturated, or a partially or fully satur
