A liquid-reservoir system (LRS) for transdermal administration of (s)-ketorolac may include a backing layer that is substantially impermeable to (s)-ketorolac, isopropyl alcohol, isopropyl myristate, oleic acid, butylated hydroxytoluene, triethanolamine, hydroxypropyl cellulose, and water it may additionally include an (s)-ketorolac reservoir layer including a liquid-reservoir gel formulation, a membrane layer, and a contact adhesive layer. The liquid-reservoir gel formulation may include: 1-15% by weight (s)-ketorolac or a salt thereof one or more drug solubilizing vehicles one or more permeation enhancers an antioxidant a thickening agent purified water and a buffering agent. A method for transdermal drug delivery includes: providing an LRS removing a release liner layer by peeling away the release liner layer, positioning the LRS onto a patients skin with a backing layer facing outward from the patients skin and applying pressure to the backing layer to non-permanently adhere the LRS to the patients skin.
