The liquid memory system (LRS) that the cutaneous penetration of acid is coughed up for (s) -one may include that the substantially impervious back sheet of acid, isopropanol, isopropyl myristate, oleic acid, butylated hydroxytoluene, triethanolamine, hydroxypropyl cellulose and water is coughed up to (s) -one It can also include that (s) -one comprising liquid memory gel preparation, film layer and contact adhesive layer coughs up sour reservoir layer. Liquid memory gel preparation may include: by weight 1% to 15% (s) -one coughs up acid or its salt One or more medicament solubilization carriers One or more penetration enhancers Antioxidant Thickener Purified water And buffer. The method of cutaneous penetration includes: to provide LRS Release liner layer is removed by removing release liner layer LRS is located on patient skin, wherein back sheet is faced out from patient skin And apply pressure to back sheet LRS is non-permanently adhered to patient skin.
