College of Medicine Pochon Cha University Industry -Academic Cooperation Foundation;EWHA University - Industry Collaboration Foundation;Industry-Academic Cooperation Foundation, Yonsei University
发明人:
Younghwa Na,Yun-Sil Lee,Jae Ho Cho
申请号：
US15986033
公开号：
US20180338948A1
申请日:
2018.05.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A composition for prevention or treatment of pulmonary fibrosis comprising chromenone derivatives represented by Formula I of the present invention or pharmaceutically acceptable salts thereof as an active ingredient, produces altered heat shock protein 27 (HSP27) dimers, thereby preventing normal HSP27 non-phosphorylated polymers from performing a chaperone function and reducing a cell protection function that chaperone originally performs. Thus the inventive composition has a remarkable inhibitory effect on pulmonary fibrosis, in particular, an irradiation-induced pulmonary fibrosis phenomenon.
