PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E2-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary fibrosis therapeutic and/or preventive agents.SOLUTION: This invention relates to a substituted phenyl compound represented by formula (I) or pharmacologically acceptable salt thereof (R1 is a carboxy group that may be protected Q is O or a group -CH2- W is N or a group -CH= R2 is an ethoxy group, a 1-propenyl group or a 1-propynyl group Z is a phenyl group or a specific group).SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】プロスタグランジンE2様のアゴニスト作用、特にEP2選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び/又は予防薬の提供。【解決手段】式(I)で表される置換フェニル化合物又はその薬理上許容される塩。(R1は保護されていてもよいカルボキシ基;QはO又は基-CH2-;WはN又は基-CH=;R2はエトキシ基、1-プロペニル基又は1-プロピニル基;Zはフェニル基又は特定の基を示す)【選択図】なし
