(57)< Abstract > As for this invention, the basis -A- of 2 value is saturated, or unsaturated homopiperijiniru which possesses one double bond is shown, here the basis -A- of the said 2 value is substituted with R2, that hydrogen, is hydroxy, C1-4 alkyl or C1-4 alkyl oxy -a1=a2-a3=a4- showing the basis of 2 value which can be substituted by when R1 hydrogen, C1-6 alkyl and aryl 1, C1-6 alkyl, C1-4 alkyl oxy carbonyl, aryl 1 carbonyl, aryl 1 C1-6 alkyl carbonyl, C1-4 alkyl carbonyl, trifluoromethyl, trifluoromethyl carbonyl, C1-6 alkyl sulfonyl, aryl 1 sulfonyl, methane sulfonyl and the benzene sulfonyl which are substituted with aryl 1, is torihuruorometansuruhoniru and jimechirusuruhuamoiru X shows O, S or NR3, R3 is C1-4 alkyl carbonyl C1-4 alkyl which is substituted with C1-4 alkyl and the aryl 2 which are substituted with hydroxy hydrogen, C1-6 alkyl, methane sulfonyl and benzene sulfonyl, torihuruorometansuruhoniru and jimechirusuruhuamoiru, by aryl 2 and when here Aryl 1 pirijiniru which can be substituted the phenyl which can be substituted by when, by when, naphthyl, it is kinoriniru or 1,3- benzojiokisoriru Aryl 2 the chemical compound formula (i) it is the phenyl which can be substituted by when, those professional drugs, N- oxide, attaching salting, 4th class amines and stereochemistry isomer It regards bottom relaxation activity. Manufacturing method of the said product, the preparation and the especially dyspepsia condition which include the said product, hypersensitiveness colon syndrome and the bottom it was obstructed, or as a medicine for dealing with a other state where it is related to the relaxation which is impaired those uses are disclosed. < Conversion 1 >本発明は、2価の基-A-が飽和、又は1つの二重結合を有する不飽和ホモピペリジニルを示し、ここで該2価の基-A-はR2で置換されており、それは水素、ヒドロキシ、C1-4アルキル又はC1-4アルキルオキシであり-a1=a2-a3=a4-が場合により置換されていることができる2価の基を示しR1が水素、C1-6アルキル、アリール1、アリール1で置換されているC1-6アルキル、C1-4アルキルオキシカルボニル、アリール1カルボニル、アリール1C1-6アルキルカルボニル、C1-4アルキルカルボニル、トリフルオロメチル、トリフルオロメチルカルボニル、C1-6アルキルスルホニル、アリール1スルホ
