JOHNS, BRIAN ALVIN,KAWASUJI, TAKASHI,TAISHI, TERUHIKO,TAODA, YOSHIYUKI
申请号：
HK12113039.2
公开号：
HK1172282B
申请日:
2012.12.18
申请国别(地区):
HK
年份:
2014
代理人:
摘要：
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ； R 1 is hydrogen or lower alkyl； X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene； R 2 is optionally substituted aryl； R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc； and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
