(4r,9as)–5–הידרוקסי–4–מתיל–6,10–דיאוקסו–10,9a,9,6,4,3 –הקסאהידרו–2h–1–אוקסא–8a,4a –דיאזא אנטרצן–7–חומצה קרבוקסילית 4,2–דיפלואורו–בנזילאמיד או מלח רוקחי שלו, תכשיר המכיל אותו ושימוש בו בטיפול או מניעת hiv
GLAXOSMITHKLINE LLC;SHIONOGI & CO. LTD.;VIIV HEALTHCARE COMPANY
发明人:
申请号：
IL18655507
公开号：
IL186555A
申请日:
2007.10.10
申请国别(地区):
IL
年份:
2016
代理人:
摘要：
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ； R 1 is hydrogen or lower alkyl； X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene； R 2 is optionally substituted aryl； R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc； and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
