A physiological signal sensor is provided, which includes an electrode layer, a pressure sensing layer and a controller. The electrode layer is disposed on the skin of a patient to sense a physiological signal therefrom. The pressure sensing layer senses the pressure signal of the electrode layer. The controller is connected to the electrode layer and the pressure sensing layer； the controller outputs the physiological signal and outputs a measurement prompt signal according to the pressure signal.一種生理訊號感測器，其包含有電極層、壓力感測層及控制器。電極層設置於皮膚上以感測生理訊號。壓力感測層感測電極層之壓力訊號。控制器與電極層及壓力感測層連接，並輸出生理訊號及根據壓力訊號輸出量測提示訊號。
