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Method of preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation
专利权人:
Shin-Etsu Chemical Co.; Ltd.
发明人:
Naosuke Maruyama,Yasuyuki Hirama
申请号:
US13909516
公开号:
US10406107B2
申请日:
2013.06.04
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
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