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GRANULATED COMPOSITE, RAPID RELEASE TABLET AND METHOD FOR PRODUCING SAME
专利权人:
Ltd.;Shin-Etsu Chemical Co.
发明人:
Yasuyuki Hirama,Naosuke Maruyama
申请号:
US16601270
公开号:
US20200038333A1
申请日:
2019.10.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided is a rapid release tablet excellent in binding capability and disintegrability and also excellent in storage stability and the like. More specifically, provided are a granulated composite comprising low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitol; a rapid release tablet comprising the granulated composite and a drug; and a method for producing a granulated composite comprising the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion, and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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