ХАРРИМАН Уильям Дон (US),ЭТЧЕЗ Роберт (US),ЛЕЙТОН Филип А. (US)
申请号:
RU2018109739
公开号:
RU2018109739A
申请日:
2016.08.24
申请国别(地区):
RU
年份:
2019
代理人:
摘要:
This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.