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Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
专利权人:
Cimex Pharma AG
发明人:
Pawan Seth
申请号:
DE60312635
公开号:
DE60312635T3
申请日:
2003.01.14
申请国别(地区):
DE
年份:
2013
代理人:
摘要:
The invention provides an itraconazole composition comprising itraconazole dispersed in a hydrophilic polymer, and, optionally, a surfactant, having a dissolution at 15 minutes between 10 and 40%, at 30 minutes between 60 and 95%, at 45 minutes more than 80%, as measured using the type II paddle method at 100 rpm according to the US Pharmacopoeia, in a dissolution medium comprised of 1000 ml HCl 0.1N. The invention also provides a composition of itraconazole comprising an inert carrier covered with at least one layer containing said itraconazole in a micronized form having a size less than 5 µm, dispersed in a hydrophilic polymer and, optionally, a surfactant, wherein the weight ratio polymer:itraconazole is equal to or higher than 1.9.The invention provides also a process for preparing said composition and a specific itraconazole solution useful in said process.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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