APPLICATION OF PYRIMIDYLAMINOBENZAMIDE DERIVATIVES FOR TREATMENT OF DISORDERS MEDIATED BY KINASE CONTAINING MOTIVES OF THE LEUCINE LIGHTNING AND STERILE ALPHA MOTIVES (ZAK)
1. The use of a pyrimidylaminobenzamide derivative of the formula I wherein (a) Py is 3-pyridyl, R is —C (O) —NRR, R is hydrogen, (lower) alkyl, (lower) alkoxy (lower) alkyl, acyloxy (lower) alkyl, carboxy (ness.) alkyl, (ness.) alkoxycarbonyl (ness.) alkyl or phenyl (ness.) alkyl, R is hydrogen, (ness.) alkyl, optionally substituted with one or more identical or different substituents R, cycloalkyl, benzocycloalkyl , heterocyclyl, an aryl group or a mono- or bicyclic heteroaryl group not containing or containing one, two or three at nitrogen in the cycle, which does not contain or contains one oxygen atom, and does not contain or contains one sulfur atom, moreover, these groups in each case do not contain substituents or contain one or more substituents, and R represents a hydroxy group, a lower alkoxy group, an acyloxy group, carboxy group, lower alkoxycarbonyl, carbamoyl, N-mono- or N, N-disubstituted carbamoyl, amino group, mono- or disubstituted amino group, cycloalkyl, heterocyclyl, aryl group or a mono- or bicyclic heteroaryl group that does not contain or contains one, two or three nitrogen atoms in the cycle, and not containing or containing one oxygen atom, and not containing or containing one sulfur atom, and these groups in each case do not contain substituents or contain one or more substituents, or where R and R together form alkylene containing four, five or six carbon atoms, optionally mono- or disubstituted (ness.) by alkyl, cycloalkyl, heterocyclyl, phenyl, hydroxy, (ness.) alkoxy, amino, mono- or disubstituted amino, oxo, pyridyl, pyrazine1. Применение производного пиримидиламинобензамида формулы Iгде(а) Ру обозначает 3-пиридил,Rобозначает -C(O)-NRR,Rобозначает водород, (низш.)алкил, (низш.)алкокси(низш.)алкил, ацилокси(низш.)алкил, карбокси(низш.)алкил, (низш.)алкоксикарбонил(низш.)алкил или фенил(низш.)алкил,Rобозначает водород, (низш.)алкил, необязательно замещенный одним или более одинаковыми или различными заместителями R, циклоалкил, бензоци
