ARMANI, ELISABETTA,CAPALDI, CARMELIDA,JENNINGS, ANDREW STEPHEN ROBERT,HEALD, ROBERT ANDREW,SUTTON, JONATHAN MARK
申请号：
ARP170101442
公开号：
AR108608A1
申请日:
2017.05.26
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
They have the properties of inhibiting human neutral reaction and their use in treatment 1. Requirement 1: a compound (1) with formula characteristics,or a pharmaceutically acceptable salt thereof, where Z is -O- or -NH； W is -H or C₁₋₄ alkyl； A is selected from the group consisting of the moieties of the group of formula (2)；X is selected from the group consisting of -C₁₋₆ alkyl, -C₂₋₆ alkylene-NRᵈRᵉ,-C832283331 and 832626 asphalt-n 83144r7491； - r7495； - r758080；-C₁₋₄ linear or branched alkylene-aryl, -C₂₋₄ linear or branched alkylene-heteroaryl； or is selected from the group consisting of the residues of the group of formulas (3),O selected from the group consisting of formula compounds (4) and (5)；R1 was selected from the group consisting of formula group residues (6)；n is an integer from 1 to 4； m is an integer from 1 to 4； t is 0 or an integer from 1 to 4； y is an integer from 1 to 4； w is an integer from 1 to 4； R² is -H or -C₁₋₄ linear or branched alkyl； R³ is -H, or is selected from the group consisting of -C₁₋₄ linear or branched alkyl or R² and R³ can together form a -C₃₋₆ cycloalkyl； R⁴ is selected from the group consisting of heteroaryl, -arylene-C₁₋₄ alkylene-NRᵈRᵉ,-arylene-C₁₋₄ alkylene-N⁺RᵃRᵇRᶜ,-heteroarylene-C₁₋₄ alkylene-NRᵈRᵉ,-heteroarylene-C₁₋₄ alkylene-N⁺RᵃRᵇRᶜ or is selected from the group consisting of the compounds of the group of formulas (7)；R⁵ is -H or is selected from the group consisting of - (CH₂) ₜ-heteroaryl, aryl-C₁₋₄ alkyleneoxy-,C8321c31833124aoc (o) - NH - linear or branched, - (ch83222248； - nr7496； - r7497；- (CH) -N R R R-Heterogeneous - (ch83222) - 8348； - n 83144r7491； - r7495； - r758080；-C (o) - n (r830421) c833183248 rent-nr7496； r74977；-C (o) n (r830421) c833183248 rent-n 831441r7491； r74758080；-C (O) OC₁₋₄ alkylene-NRᵈRᵉ,-C (O) OC₁₋₄ alkylene-N⁺RᵃRᵇRᶜ,-O-C (O) -C alquilen-NR R-O-C (O) -C alquilen-N R R R-(ch832222) - 8348nhc (o) - c8332131-8324 lessor-nr7496；-(ch832222) - 8348nhc (o) - c8332131-832424 lessor-n 83144r7491；
