MELISSA FLEURY,ROLAND GENDRON,ERIK FENSTER,ADAM D. HUGHES
申请号：
ARP120104101
公开号：
AR088618A1
申请日:
2012.11.01
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
These compounds have adrenergic inhibitory activity. Pharmaceutical compounds including these compounds； methods of using these compounds； and processes and middlemen for the manufacture of these compounds. Used to treat high blood pressure, heart failure, lung and kidney 1. Requirement 1: a compound (1) with formula characteristics,where R¹ is selected from H, -C₁₋₈ alkyl,-No. c832183-83331-83231 - arilo c8326231-83218320；-C8332131 - heterosexual c833218329；-C₃₋₇ cycloalkyl,-[(D 8322) 8322；] [D 8321]；-Lease of building c83218c83316c-oc (o) R1 83044；- Rent C₁₋₆-NR¹¹R¹²,-C83218c83331-8326c (o) R1 m3；-C₀₋₆morpholinyl alkyl, -C₁₋₆-SO₂-C₁₋₆ alkyl,Or other members of formula group (2)；R¹⁰ is selected from -alkyl C₁₋₆,-O-C₁₋₆ alkyl,-C₃₋₇ cycloalkyl,-O-C₃₋₇ cycloalkyl,phenyl, -O-phenyl, -NR¹¹R¹²,-CH (R) -NH-CH (R) -NHC (O) O-alquilo Cy -CH (NH) CH COOCHand R¹¹ and R¹² are independently selected from H, -C₁₋₆ alkyl,and benzyl； or R¹¹ and R¹² are taken together as - (CH₂) ₃₋₆-,-C (O) - (CH) -o - (CH) O (CH) -R¹³ is selected from -O-C₁₋₆ alkyl,-O-benzyl, and -NR¹¹R¹²；and R¹⁴ is -C₁₋₆ alkyl or -C₀₋₆-C₆₋₁₀-aryl alkyl；R¹⁵ is H, -CH₃,-CH (CH)fenilo o bencilo R es -OR o -CH ORR3 is h-o-ch8323；Where H - (c) (o) - lessor c832131；-C (o) - CH (r Square) - nh83222；-C (O) -CH (R²²) -NHC (O) O-C₁₋₆ alkyl,o -P (O) (OR)R2 is h, ch832323,-CH (CH)phenyl, or benzyl； R²³ is H, -C₁₋₆ alkyl,o fenilo o R se toma junto con R para formar -OCR R - o -CH O-CR R -R3 is selected from h to ch-832323,R83099a and r8310a were selected independently from h-c83218c-tar；and -O-C₃₋₇ cycloalkyl,O r83099 and r8310 together = O； or R * with R3 together - ch8322a-o-ch-832222a-o-ch832222 -；O R2 and R3 are - ch-83323；Z is selected from - ch-y-n -；R⁴ is selected from H, -C₁₋₈ alkyl,-Cquile-O-C₁₋₈ alkyl,-No. c832183-83331-83231 - arilo c8326231-83218320；-alkyl C₁₋₃-O-aryl C₆₋₁₀,-C8332131 - heterosexual c833218329；-C₃₋₇ cycloalkyl,-[(D 8322) 8322；] [D 8321]；- Rent C₁₋₆-OC (O) R⁴⁰,-No. c83218331 - No. 8326285； No. 1 - N
