MIDDELBEEK, HANS ALMER,米德比克 汉斯,米德比克 漢斯,SMIT, JOZEFUS A. C.,史密特 乔瑟夫斯,史密特 喬瑟夫斯
申请号：
TW099113081
公开号：
TWI468157B
申请日:
2010.04.26
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention pertains to a process for the preparation of a fast-disintegrating tablet containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.本發明係關於一種製備含有藥物之快速崩解錠劑的方法,其包含以下步驟:提供包含該藥物之流體調和物,提供具有至少一空穴形成於其中之固態元件,冷卻該固態元件至低於該調和物之凝固溫度的溫度,以該流體調和物填充該空穴,固化存在於該空穴內的調和物以形成包含該藥物之固態丸粒,而不主動形塑該丸粒之全部表面,由該空穴取出該丸粒及在真空中乾燥該丸粒而獲得該錠劑。本發明也關於一種用於進行此種方法的系統及含有所得之錠劑的包裝物。15...容器16...把手100...空穴盤102,103,104...行105...冷卻元件120...收集元件121,122,123...格子130...分配單元131...托架132,133,134...注射針152,153,154...管
