Hans Almer Middelbeek;Jozefus A. C. Smit;Jacobus Johannes Adriana Maria Verheezen
发明人:
Hans Almer Middelbeek,Jozefus A. C. Smit,Jacobus Johannes Adriana Maria Verheezen
申请号：
US13266511
公开号：
US09095516B2
申请日:
2010.04.28
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.
