MIDDELBEEK HANS ALMER,SMIT JOZEFUS A C,VERHEEZEN JACOBUS JOHANNES ADRIANA MARIA
申请号：
IN7963/CHENP/2011
公开号：
IN2011CN07963A
申请日:
2011.10.31
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.
