A compound having the formula (I) ** Formula ** or one of its stereochemically isomeric forms, wherein R 1 is phenyl or pyridinyl, each optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, C 1 alkyl -6, trifluoromethyl, C1-6-oxy alkyl, (C3-6 cycloalkyl) C1-3-oxy alkyl and trifluoromethoxy； R2 is a radical of the formula -L1-NR3R4； L1 is a covalent bond, CH2, CH (CF3) or C (>； = O)； R3 is hydrogen or methyl； R4 is selected from the group consisting of hydrogen； C1-3 alkyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, hydroxy, C1-3 alkoxy, mono- and di (C1-3 alkyl) amino, C3-6 cycloalkyl, phenyl, 3 , 4,5-trimethoxyphenyl, pyridinyl, halo substituted pyridinyl, morpholinyl, pyrrolidinyl, piperidinyl, and methyl substituted piperidinyl； C3-6 cycloalkyl； tetrahi dropiranyl； 1-methylpiperidin-4-yl； 4-hydroxycyclohexan-1-yl； 3,4,5-trimethoxyphenyl； C1-3 alkylcarbonyl； and pyridinyl； or NR3R4 is pyrrolidinyl, piperidinyl or morpholinyl, each optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, trifluoromethyl, hydroxyl, C1-3-oxy alkyl, mono- and di (C1-3 alkyl) amino, hydroxy C1-3 alkyl, halo C1-3 alkyl, and methoxy C1-3 alkyl； or 4- methylpiperazin-1-yl； or a pharmaceutically acceptable salt or a solvate thereof.Un compuesto que tiene la fórmula (I)**Fórmula** o una de sus formas estereoquímicamente isoméricas, donde R1 es fenilo o piridinilo, cada uno opcionalmente sustituido con 1 o 2 sustituyentes independientemente seleccionados del grupo que consiste en halo, alquilo de C1-6, trifluorometilo, alquil C1-6-oxi, (cicloalquil C3- 6)alquil C1-3-oxi y trifluorometoxi； R2 es un radical de fórmula -L1-NR3R4； L1 es un enlace covalente, CH2, CH(CF3) o C(>；=O)； R3 es hidrógeno o metilo； R4 se selecciona del grupo que consiste en hidrógeno； alquilo de C1-3 opcionalmente sustituido con 1 o 2 sustituyentes independ
