A device (6) to sample molecules of biological interest is described. The device (6) includes capture zones (10) whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device (6) is neither invasive nor aggressive.In particular, the device comprises tiered capture zones (10) located on a support (12) fabricated using microtechnology techniques the capture zones (10) may advantageously be functionalised.