THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人:
Nimalan Thavandiran,Milica Radisic,Peter Zandstra
申请号：
US14650227
公开号：
US10034738B2
申请日:
2013.12.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.
