PROBLEM TO BE SOLVED: To provide a fibroblast proliferation promoter, an MMP-1(matrix metalloprotease-1) activity inhibitor, an elastase activity inhibitor, a profilaggrin production-promoting activity, a filaggrin production promoter or an antiaging agent, based on having found a substance as an active ingredient for the agents, which has excellent fibroblast proliferation-promoting effect, MMP-1 activity inhibitory effect, elastase activity inhibitory effect, profilaggrin production-promoting effect, filaggrin production-promoting effect or antiaging effect.SOLUTION: The fibroblast proliferation promoter, the MMP-1(matrix metalloprotease-1) activity inhibitor, the elastase activity inhibitor, the profilaggrin production promoter, the filaggrin production promoter or the antiaging agent are each included with davidigenin as the active ingredient for the respective agents. Also, a skin care preparation for external use for antiaging is compounded with davidigenin.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れた線維芽細胞増殖促進作用、マトリックスメタロプロテアーゼ-1(MMP-1)活性阻害作用、エラスターゼ活性阻害作用、プロフィラグリン産生促進作用、フィラグリン産生促進作用又は抗老化作用を有する物質を見出し、それを有効成分とする線維芽細胞増殖促進剤、MMP-1活性阻害剤、エラスターゼ活性阻害剤、プロフィラグリン産生促進剤、フィラグリン産生促進剤又は抗老化剤を提供する。【解決手段】線維芽細胞増殖促進剤、MMP-1活性阻害剤、エラスターゼ活性阻害剤、プロフィラグリン産生促進剤、フィラグリン産生促進剤又は抗老化剤の有効成分として、ダビジゲニンを含有させる。また、老化防止用皮膚外用剤に、ダビジゲニンを配合する。【選択図】なし
