Molecular probe precursor for islet imaging and use thereof

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专利权人:

国立大学法人京都大学;アークレイ株式会社

发明人:

稲垣 暢也,佐治 英郎,豊田 健太郎,木村 寛之,平尾 佳,永川 健児

申请号：

JP2009535517

公开号：

JPWO2010032509A1

申请日:

2009.03.31

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

A molecular probe precursor for islet imaging is provided. A polypeptide represented by any one of the following formulas (1) to (12) or a polypeptide having homology with the polypeptide. * -DLSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (1) *-LSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (2) *-SKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (3) *-KQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (4) * SG4PS-PS2 * 4 * -LSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (6) *-SK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (7) *-K * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (8) DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 * 9EELSRLQPSLKME * EE SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (11) K * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 (12)膵島イメージング用分子プローブ前駆体を提供する。下記式(１)～(１２)のいずれかで表されるポリペプチド又は前記ポリペプチドと相同性を有するポリペプチド。*-DLSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2(1)*-LSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2(2)*-SKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2(3)*-KQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2(4)*-DLSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2(5)*-LSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2(6)*-SK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2(7)*-K*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2(8)DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH2(9)LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH2(10)SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH2(11)K* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH2(12)

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/