The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.本發明提供經分離之單株抗體、尤其人類抗體,其以高親和力結合至IP-10、抑制IP-10結合至其受體、抑制IP-10誘導之鈣流動且抑制IP-10誘導之細胞遷移。亦提供編碼本發明抗體之核酸分子、用於表現本發明抗體之表現載體、宿主細胞及方法。亦提供包括本發明抗體之免疫偶聯物、雙特異性分子及醫藥組合物。本發明亦提供使用本發明抗體抑制IP-10活性之方法,包含治療各種發炎疾病及自體免疫疾病之方法。
