KAMRUD, Kurt I.,SMITH, Jonathan F.,MAUGHAN, Maureen
申请号：
HK16105221.2
公开号：
HK1217216A
申请日:
2016.05.09
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5 replication recognition sequence, wherein at least one initiation codon has been removed from the 5 replication recognition sequence b) a nucleotide sequence encoding an alphavirus structural protein and c) an alphavirus 3 replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5 and 3 replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus nonstructural proteins.
