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RABIES VIRUS-BASED RECOMBINANT IMMUNOCONTRACEPTI VE COMPOSITIONS AND METHODS OF USE
专利权人:
发明人:
RUPPRECHT CHARLES U S A,WU XIANFU U S A
申请号:
IN1034/KOLNP/2011
公开号:
IN300529B
申请日:
2009.08.20
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
Described herein are recombinant rabies viruses comprising a heterologous nucleic acid sequence encoding an immunocontraceptive protein, such as gonadotropin-releasing hormone (GnRH) or zona pellucida 3 (ZP3). The recombinant rabies viruses disclosed herein are recovered by reverse genetics, replicate efficiently, elicit rabies virus neutralizing antibodies and immunocontraceptive peptide-specific antibodies in vaccinated animals, and protect vaccinated animals against wild-type rabies virus challenge. Further provided is a method of immunizing a non-human animal against rabies virus infection and simultaneously inhibiting fertility of the animal, comprising administering an immunogenic composition comprising one or more of the recombinant rabies viruses described herein. WO2010033337A1
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中国工程科技知识中心
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