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ВЕКТОРЫ ПАРАПОКСВИРУСА, СОДЕРЖАЩИЕ АНТИГЕН ВИРУСА БЕШЕНСТВА
专利权人:
ЭЙЭЙЧ ЮСЭЙ 42 ЭЛЭЛСИ (US)
发明人:
МАРТЭНО Оливье Мишель (US),РИДДИ Нанда Кумар Дамаварапу (IN)
申请号:
RU2012149036/10
公开号:
RU2012149036A
申请日:
2011.04.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Recombinant parapoksvirus comprising parapoksvirus and heterologous DNA taken from beshenstva.2 virus. Recombinant parapoksvirus according to claim 1, characterized in that the virus is parapoksvirus Parapoxvirus ovis (ORFV) .3. Recombinant parapoksvirus according to claim 2, characterized in that the strain represents parapoksvirus Parapoxvirus ovis D1701.4. Recombinant parapoksvirus according to claim 1, characterized in that the heterologous DNA includes a gene coding for G-protein of rabies virus or a fragmenty.5. Recombinant parapoksvirus according to claim 1, characterized in that the heterologous DNA comprises SEQ ID NO: 4 or a sequence having at least about 98% identity to SEQ ID NO: 4.6. Recombinant parapoksvirus according to claim 1, characterized in that the heterologous DNA fragment is inserted into the HindIII H / H strain Parapoxvirus ovis D1701.7. Recombinant parapoksvirus according to claim 6, characterized in that the heterologous DNA inserted into the coding sequence of VEGF or adjacent noncoding sequences within the fragment HindIII H / H strain Parapoxvirus ovis D1701.8. Parapoksvirus according to claim 1, characterized in that parapoksvirus is Parapoxvirus ovis D1701-V-RabG.9. A method of producing recombinant parapoksvirusa according to claim 1, comprising the insertion of heterologous DNA into the genome parapoksvirusa.10. A method according to claim 9, characterized in that parapoksvirus represents Parapoxvirus ovis.11. A method according to claim 10, characterized in that the strain represents parapoksvirus Parapoxvirus ovis D1701.12. A method according to claim 9, characterized in that the heterologous DNA includes a gene coding for G-protein of rabies virus or a fragmenty.13. The method of claim 9, wherein the heterologous DNA comprises SEQ ID NO: 4 or a sequence having at least n1. Рекомбинантный парапоксвирус, включающий парапоксвирус и гетерологичную ДНК, взятую из вируса бешенства.2. Рекомбинантный парапоксвирус по п.1, отличающийся
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