RECOMBINANT ONCOLYTIC VIRUS

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专利权人:

Inc.;Georgia State University Research Foundation

发明人:

Ming Luo

申请号：

US16614441

公开号：

US20200199624A1

申请日:

2018.05.16

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Recombinant viral vectors are disclosed that contain a nucleic acid encoding a Second Mitochondria-derived Activator of Caspases (Smac) protein inserted within an RNA virus genome, wherein the Smac protein specifically binds to at least a portion of an Inhibitor of Apoptosis Protein (IAP). Also disclosed are methods of treating cancer using the disclosed vectors.

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