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Rabies virus-based recombinant immunocontraceptive compositions and methods of use
专利权人:
Xianfu Wu
发明人:
Xianfu Wu,Charles Rupprecht
申请号:
US13062680
公开号:
US08524247B2
申请日:
2009.08.20
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Described herein are recombinant rabies viruses comprising a heterologous nucleic acid sequence encoding an immunocontraceptive protein, such as gonadotropin-releasing hormone (GnRH) or zona pellucida 3 (ZP3). The recombinant rabies viruses disclosed herein are recovered by reverse genetics, replicate efficiently, elicit rabies virus neutralizing antibodies and immunocontraceptive peptide-specific antibodies in vaccinated animals, and protect vaccinated animals against wild-type rabies virus challenge. Further provided is a method of immunizing a non-human animal against rabies virus infection and simultaneously inhibiting fertility of the animal, comprising administering an immunogenic composition comprising one or more of the recombinant rabies viruses described herein.
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