DR SUSHAMA R CHAPHALKAR,DR AMIT GUPTA,MISS PALLAVI R KHAMKAR
申请号：
IN2603/MUM/2014
公开号：
IN2014MU02603A
申请日:
2014.08.13
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention relates to formulations which contain the aqueous extract of stem and leaf of plant Dipterocanihus palulus. These aqueous extract used as protein antigen and other secondary metabolites in the formulation instead of rabies protein antigen (rabipur vaccine) which is available in the market and is to be able to detect the immunological methods of the immune response inducing a specific as well as non specific immune response and to protecting the animals from infection by rabies virus. Rabies is a viral (bullet-shaped and enveloped particle on average 75 -180 run) disease and is an acute, neurological disease caused by a neurotropic RNA virus that causes acute encephalitis in warm-blooded animals and its genome encodes five proteins designated as nucleo-protein, phosphor-protein, matrix-protein, glycol-protein and polymerase and is transmissible to all mammals by inoculation or inhalation of infectious virus. For the last so many years, rabies virus continues to be an important threat of human and veterinary infection because of extensive reservoirs in diverse species of wild life. This rabies virus is reported in various several countries like India, United Kingdom, Australia, Japan and other countries. The disease can be transmitted from one species to another commonly by infected dog to humans. Once the human is infected, this virus travels to the brain through peripheral nerves and the virus will be retaining for a long period of time (up to several months). So this virus can be effected variety of cells in the brain including cerebellum, the Purkinje cells etc and also spread from the central nervous system, via neurons, to the eyes, skin and various other sites (kidneys, pancreatic acinar cells) and the salivary glands. Infection of the brain leads to encephalitis and neural degeneration, finally leads to coma and death. Nevertheless, a good immune response that eliminates the infection can be achieved using a vaccine even after infection because o
