The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.本發明係有關於一種如式(I)之雙環雜環化合物、或其互變異構物、其立體化學異構物、其N-氧化物、其醫藥上可接受之鹽類、或其溶劑合物:其中,R1、R2a、R2b、R3a、R3b、R5、R6、R7、R8、R9、p及E係如說明書中所定義。本發明更提供一包含此化合物之醫藥組成物、及此化合物於疾病(如,癌症)治療上之用途。